منابع مشابه
Switching myelination on and off
Schwann cells are remarkably plastic cells that can both form and stably maintain myelin sheaths around axons and also rapidly dedifferentiate upon injury. New findings (Parkinson, D.B., A. Bhaskaran, P. Arthur-Farraj, L.A. Noon, A. Woodhoo, A.C. Lloyd, M.L. Feltri, L. Wrabetz, A. Behrens, R. Mirsky, and K.R. Jessen. 2008. J. Cell Biol. 181:625-637) indicate that the transition between these di...
متن کاملRab35, acting through ACAP2 switching off Arf6, negatively regulates oligodendrocyte differentiation and myelination
Oligodendrocyte precursor cells differentiate to produce myelin sheaths that insulate axons to ensure fast propagation of action potentials. Many aspects of differentiation are regulated by multiple extracellular signals. However, their intracellular signalings remain elusive. We show that Rab35 and its effector, ACAP2, a GTPase-activating protein that switches off Arf6 activity, negatively reg...
متن کاملSwitching immune signals on and off
Bruton's tyrosine kinase, an enzyme that is important for B cell function, can be activated in a number of ways. Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. eLife 4:e06074. Image The enzyme Btk has crucial roles in tyrosine kinase signaling and the development of certain immune cells B cells are immune cells that protect the body against pathogens by maki...
متن کاملSwitching genes on and off in haemopoiesis.
At present, the molecular mechanisms by which stem cells commit to and differentiate towards specific lineages are poorly characterized, and will need to be better understood before stem cells can be exploited fully in experimental and clinical settings. Transcriptional regulation, the ability to turn genes on and off, lies at the heart of these processes of lineage commitment and specification...
متن کاملSleep: Switching Off the Off-Switch
What are the synaptic drives controlling the sleep-wake circuitry in the mammalian brain? In a new study it was found that GABAergic cells in posterior lateral hypothalamus inhibit sleep-promoting anterior hypothalamic cells to cause waking, whereas their inhibition augments sleep.
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2008
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.200804136